WISDOM initiative aims to demonstrate the relevance and the impact of the grid approach to address drug discovery for neglected and emergent diseases. It gathers several partners around the world conscious of the urgency of working on these diseases. They are using grid infrastructure to organise and accelerate their research. They deploy production experiment of virtual screening at a large scale against diseases, called a data challenge. The acronyme WISDOM, for Wide In Silico Docking On Malaria, comes from the first screening experiment at a large scale against malaria and is now used as a generic name for the initiative.